Background: The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF).
Objectives: To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF.
The “Evaluation of Pimobendan In dogs with Cardiomegaly caused by preclinical mitral valve disease” (EPIC) study1 was a multicenter, blinded, randomized, placebo-controlled clinical trial evaluating the effect of pimobendan in delaying the onset of clinical signs in dogs with cardiac enlargement secondary to myxomatous mitral valve disease (MMVD).
Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disease in the dog. Progressive degenerative lesions of the valve result in mitral regurgitation (MR) imposing a gradually increasing chronic volume load on the left side of the heart. In some dogs, the volume load will result in clinically detectable enlargement of the left side of the heart and might eventually result in the development of signs of congestive heart failure (CHF), that is, pulmonary venous congestion and edema.
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Extrait : “An 11-year-old, 12.5-kg, mixed-breed, male dog presented with a 4-day history of fatigue, abdominal enlargement, and anorexia. The dog became acutely lethargic a few hours before presentation. Clinical examination confirmed lethargy and revealed tachycardia (220 bpm), tachypnea (25 breaths/min), muffled heart sounds, a weak peripheral pulse, jugular distention, a capillary refill time of >2 sec, and ascites.“
Auteurs : Drs. C. Bille, E. Bomassi et S. Libermann
Extrait : “A 7-year-old castrated male Labrador retriever was examined for a 10-day history of weakness and syncope. Physical examination revealed bradycardia and a grade III/VI left apical systolic heart murmur. Electrocardiography demonstrated bradycardia, absence of P waves and an atrio-ventricular nodal escape rhythm.“
Auteurs : Drs. E. Bomassi, J.-F. Rousselot, S. Libermann, I. Raymond Letron, S. Etchepareborde, C. Misbach
Extrait : “Heart disease is an important cause of morbidity and mortality in cats, but there is limited evidence of the benefit of any medication. Hypothesis: The angiotensin-converting enzyme inhibitor benazepril would delay the time to treatment failure in cats with heart disease of various etiologies.“
Auteurs: Drs. Jonathan N. King, Mike Martin, Valérie Chetboul, Luca Ferasin, Anne T. French, Günther Strehlau, Wolfgang Seewald, Sarah G. W. Smith, Simon T. Swift, Susan L. Roberts, Andrea M. Harvey, Christopher J. L. Little, Sarah M. A. Caney, Kerry E. Simpson, Andrew H. Sparkes, Eleanor J. Mardell, Eric Bomassi, Claude Muller, John P. Sauvage, Armelle Diquélou, Matthias A. Schneider, Laurence J. Brown, David D. Clarke, Jean-Francois Rousselot.
Heart disease is an important cause of morbidity and mortality in cats, but there is limited evidence of the benefit of any medication.
Auteurs : Drs. Jonathan N. King1, Mike Martin2, Valérie Chetboul3, Luca Ferasin4, Anne T. French5, Günther Strehlau6, Wolfgang Seewald1, Sarah G. W. Smith7, Simon T. Swift8, Susan L. Roberts9, Andrea M. Harvey10, Christopher J. L. Little11, Sarah M. A. Caney12,Kerry E. Simpson13, Andrew H. Sparkes14, Eleanor J. Mardell15, Eric Bomassi16, Claude Muller17, John P. Sauvage18, Armelle Diquélou19, Matthias A. Schneider20, Laurence J. Brown21, David D. Clarke22, Jean-Francois Rousselot23 10-07-2019 E-mail : ebomassi@chvcordeliers.com Cet article a été publié dans : J Vet Intern Med. (2019);33 : p 2559-2571
A 7-year-old castrated male Labrador retriever was examined for a 10-day history of weakness and syncope. Physical examination revealed bradycardia and a grade III/VI left apical systolic heart murmur. Electrocardiography demonstrated bradycardia, absence of P waves and an atrio-ventricular nodal escape rhythm.
